Fast dissolving tablets are useful in patients such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in swallowing conventional tablets or capsules leading to ineffective therapy. Ketorolac tromethamine is a non-selective COX Inhibitor used as an analgesic in moderately severe acute pain. Ketorolac tromethamine tends to cause severe gastric irritation within short course of therapy. Hence the present study is aimed at developing and evaluating fast dissolving tablets of ketorolac tromethamine using superdisintegrants like agar, sodium starch glycolate and crosspovidone to reduce gastric irritation and enhance the patients’ compliance during administration. Ketorolac tromethamine fast dissolving tablets were prepared by direct compression method. Tablets were evaluated for their physicochemical properties and in-vitro release studies. The hardness (5-7 kg/cm2), friability (0.1-0.4%), drug content (81-100%) and disintegration time (29 - 62 seconds) of fast dissolving tablets were found to be uniform and reproducible. Dissolution of tablets was not directly proportional to the concentration of superdisintegrants but showed varying response according to the nature of superdisintegrants used. The formulations prepared with 10% SSG were found to be better in terms of disintegration and in-vitro drug release profile compared to other formulations.
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